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A case-control study of 53 patients with vitamin B 12 deficiency in a geriatric primary care setting found that current use of PPIs/H 2 RAs for 12 or more months was associated with vitamin B 12 deficiency (OR, 4.45 [95% CI, 1. .34]) but reported no association for past or short-term use. 7 In contrast, a cross-sectional study of 542 Long-term use of heartburn/acid reflux medication may be linked to vitamin B12 deficiency. hailey fe 1.5/30 reviews PPIs such as Omeprazole, if used for more than 6 months can cause Vitb12 deficiency clinical manifestations including Neurotoxicity and cognitive decline by oxidative stress mechanisms [11]. Nowadays regular use of specialised oral supplements or injections of vitamin B12 will treat or prevent deficiency completely. Mild deficiency can still cause
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